Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.30 |
| ▸ | PNMT | P11086 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27723961 | 0.77 | PNMT (0.30) | PNMT | |
| SCHEMBL27656977 | 0.74 | OPRM1 (0.36) | PNMTKDM4ESMN1; SMN2 | |
| SCHEMBL27719617 | 0.74 | L3MBTL1 (0.41) | AURKARPS6KB1GPR88 | |
| SCHEMBL28264010 | 0.70 | EPHX1 (0.39) | PNMTKDM4ESMN1; SMN2 | |
| SCHEMBL28857685 | 0.68 | CYP2C19 (0.47) | AURKARPS6KB1GPR88SMN1; SMN2 | |
| SCHEMBL27473189 | 0.68 | DPP4 (0.41) | PNMTKDM4ESMN1; SMN2 | |
| SCHEMBL27723976 | 0.68 | PPARG (0.40) | KDM4ESMN1; SMN2 | |
| SCHEMBL28136810 | 0.67 | KMT2A (0.38) | PNMTKDM4ESMN1; SMN2 | |
| SCHEMBL28306686 | 0.67 | CYP1A2 (0.54) | KDM4ESMN1; SMN2 | |
| SCHEMBL28837383 | 0.67 | ENPP2 (0.49) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102516192-A | Antagonists of the vanilloid receptor subtype 1 (VR1) and uses thereof | ABBOTT LAB | 2012-06-27 | — | — | CN | disclosed |
| CN-101248052-A | Vanilloid receptor subtype 1(VR1) antagonists and uses thereof | ABBOTT LAB (US) | 2008-08-20 | — | — | CN | disclosed |