Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.50 |
| ▸ | DPP7 | Q9UHL4 | 4/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.42 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.42 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.39 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.39 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.38 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.38 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.38 |
| ▸ | DDAH1 | O94760 | 2/20 | 0.36 |
| ▸ | NOS1 | P29475 | 4/20 | 0.35 |
| ▸ | ARG1 | P05089 | 3/20 | 0.34 |
| ▸ | ARG2 | P78540 | 3/20 | 0.34 |
| ▸ | NOS3 | P29474 | 3/20 | 0.34 |
| ▸ | NOS2 | P35228 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL28422011 | 0.88 | GSR (0.54) | GSRDPP7DPP8DPP9GNAI3 | |
| Asparagine SCHEMBL27748103 | 0.84 | SLC1A2 (0.39) | SLC1A2SLC1A1SLC1A3GRIK1GRIK2 | |
| Bicarbonate SCHEMBL29505196 | 0.81 | GBA2 (0.35) | — | |
| Lysine SCHEMBL27898144 | 0.81 | GSR (0.54) | GSRDPP7DPP8DPP9GNAI3 | |
| Acetic Acid SCHEMBL28427571 | 0.79 | GBA2 (0.34) | — | |
| Lysine SCHEMBL1484683 | 0.79 | GSR (0.80) | GSRDPP7DPP8DPP9GNAI3 | |
| Lysine SCHEMBL7909339 | 0.79 | GSR (0.80) | GSRDPP7DPP8DPP9GNAI3 | |
| Lysine SCHEMBL1484680 | 0.79 | GSR (0.80) | GSRDPP7DPP8DPP9GNAI3 | |
| 2-Ethylhexanoic Acid SCHEMBL29606937 | 0.79 | CA2 (0.56) | SLC1A2SLC1A1SLC1A3GRIK1GRIK2 | |
| Lysine SCHEMBL28979846 | 0.76 | GSR (0.51) | GSRDPP7DPP8DPP9GNAI3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101327450-A | Aminoacid ion liquid carried Salen metallic catalyst and preparation method | UNIV ZHEJIANG (CN) | 2008-12-24 | — | — | CN | disclosed |