Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27754807 | 0.96 | TSHR (0.42) | PKMTSHRKMT2AMEN1KDM4E | |
| SCHEMBL27693489 | 0.85 | POLB (0.36) | PKMTSHRKMT2AMEN1KDM4E | |
| SCHEMBL27831737 | 0.85 | MEN1 (0.37) | PKMTSHRKMT2AMEN1KDM4E | |
| SCHEMBL27726282 | 0.85 | MAPT (0.41) | KMT2AMEN1POLBALDH1A1SMN1; SMN2 | |
| SCHEMBL27642279 | 0.84 | ALDH1A1 (0.41) | TSHRKDM4EPOLBGAAALDH1A1 | |
| SCHEMBL27675176 | 0.84 | TSHR (0.42) | PKMTSHRPOLBALDH1A1LMNA | |
| SCHEMBL27743079 | 0.84 | PKM (0.41) | PKMKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL27989710 | 0.82 | L3MBTL1 (0.39) | KMT2AMEN1POLBALDH1A1LMNA | |
| SCHEMBL27788104 | 0.82 | CHRM2 (0.50) | TSHRKDM4EPOLBSMN1; SMN2 | |
| SCHEMBL27448396 | 0.82 | ALDH1A1 (0.36) | TSHRKMT2AMEN1KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101305001-A | Indolizine derivatives as ligands of the CRTH2 receptor | ARGENTA DISCOVERY LTD (GB) | 2008-11-12 | — | — | CN | disclosed |
| CN-101243086-A | Indolizine derivatives and their use as CRTH2 antagonists | ARGENTA DISCOVERY LTD (GB) | 2008-08-13 | — | — | CN | disclosed |