Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 4/20 | 0.36 |
| ▸ | PHGDH | O43175 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27754807 | 0.87 | TSHR (0.42) | MEN1KMT2APOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL27693489 | 0.86 | POLB (0.36) | MEN1KMT2APOLBPHGDHALDH1A1 | |
| SCHEMBL27735019 | 0.85 | PKM (0.45) | MEN1KMT2APOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL27726282 | 0.82 | MAPT (0.41) | MEN1KMT2APOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL27989710 | 0.82 | L3MBTL1 (0.39) | MEN1KMT2APOLBALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL27739197 | 0.81 | CA2 (0.40) | MEN1KMT2APOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL27743251 | 0.79 | LMNA (0.43) | POLBALDH1A1LMNAGAAMAPT | |
| SCHEMBL27888400 | 0.78 | KMT2A (0.35) | MEN1KMT2APOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL27830510 | 0.76 | CA12 (0.35) | SMN1; SMN2TSHR | |
| SCHEMBL27675176 | 0.76 | TSHR (0.42) | POLBALDH1A1LMNATSHRPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105143206-A | Pyrimidine-2,4-diamine derivatives for treatment of cancer | THOMAS HELLEDAYS STIFTELSE F R MEDICINSK FORSKNING | 2015-12-09 | — | — | CN | disclosed |
| CN-102307872-A | BCL-2-selectively apoptosis-inducing agents for the treatment of cancer and immune diseases | ABBOTT LAB | 2012-01-04 | — | — | CN | disclosed |
| CN-102036996-A | Bridged heterocycles as HIV integrase inhibitors | BRISTOL MYERS SQUIBB CO | 2011-04-27 | — | — | CN | disclosed |