Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.51 |
| ▸ | LCK | P06239 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | PNLIP | P16233 | 2/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 3/20 | 0.46 |
| ▸ | AURKA | O14965 | 3/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.46 |
| ▸ | RAF1 | P04049 | 2/20 | 0.46 |
| ▸ | PLK4 | O00444 | 2/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.46 |
| ▸ | ABL1 | P00519 | 2/20 | 0.46 |
| ▸ | FYN | P06241 | 2/20 | 0.46 |
| ▸ | LYN | P07948 | 2/20 | 0.46 |
| ▸ | RET | P07949 | 2/20 | 0.46 |
| ▸ | SRC | P12931 | 2/20 | 0.46 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.46 |
| ▸ | AXL | P30530 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27740978 | 0.88 | PNLIP (0.51) | EGFRERBB2LCKNPC1PNLIP | |
| SCHEMBL27720113 | 0.84 | BRAF (0.48) | EGFRERBB2LCKNPC1PNLIP | |
| SCHEMBL27720157 | 0.81 | MAPT (0.64) | EGFRERBB2LCKNPC1PNLIP | |
| SCHEMBL27720109 | 0.78 | MAPK14 (0.52) | EGFRKDRSRCMAPK14MET | |
| SCHEMBL27720100 | 0.78 | BRAF (0.63) | EGFRERBB2LCKNPC1PNLIP | |
| SCHEMBL27720129 | 0.77 | MEN1 (0.66) | EGFRERBB2LCKNPC1KDR | |
| SCHEMBL27720191 | 0.77 | CDK8 (0.55) | LCKNPC1KDRAURKARPS6KB1 | |
| SCHEMBL27720107 | 0.76 | MEN1 (0.61) | NPC1KDRRAF1MEN1BRAF | |
| SCHEMBL27720106 | 0.76 | RAF1 (0.51) | EGFRERBB2LCKNPC1PNLIP | |
| SCHEMBL31084744 | 0.75 | ERBB2 (0.74) | EGFRERBB2LCKKCNH2AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101298427-B | Diaryl urea compound and use thereof | GUANGZHOU INST BIOMED & HEALTH | 2012-03-21 | — | — | CN | disclosed |
| CN-101298427-A | Diaryl urea compound and use thereof | GUANGZHOU INST BIOMED & HEALTH (CN) | 2008-11-05 | — | — | CN | disclosed |