Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.54 |
| ▸ | MMP13 | P45452 | 1/20 | 0.54 |
| ▸ | MMP14 | P50281 | 1/20 | 0.54 |
| ▸ | CCNC | P24863 | 2/20 | 0.54 |
| ▸ | CDK8 | P49336 | 2/20 | 0.54 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.54 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.47 |
| ▸ | GHSR | Q92847 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | CD38 | P28907 | 1/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7497614 | 0.82 | FGFR1 (0.62) | CCNCCDK8CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL2303019 | 0.76 | CCNC (0.48) | MMP2MMP13MMP14CCNCCDK8 | |
| SCHEMBL1513359 | 0.75 | JAK2 (0.53) | CCNCCDK8CDK19GHSRJAK2 | |
| Ethoxycarbonyl Group SCHEMBL28015039 | 0.73 | MMP2 (0.51) | MMP2MMP13MMP14CCNCCDK8 | |
| SCHEMBL5487018 | 0.72 | CYP11B2 (0.74) | MMP2MMP13MMP14CYP11B1CYP11B2 | |
| SCHEMBL14527403 | 0.71 | GHSR (0.56) | CYP11B1CYP11B2CYP19A1GHSRMKNK1 | |
| SCHEMBL9001704 | 0.71 | CYP11B1 (0.47) | MMP2MMP13MMP14CCNCCDK8 | |
| SCHEMBL9709514 | 0.71 | EPHX2 (0.52) | MMP2MMP13MMP14CYP11B1CYP11B2 | |
| SCHEMBL2302267 | 0.71 | CCNC (0.52) | MMP2MMP13MMP14CCNCCDK8 | |
| SCHEMBL2302268 | 0.71 | CCNC (0.52) | MMP2MMP13MMP14CCNCCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101316818-B | 3-amino-1-arylpropyl indoles and aza-substituted indoles | HOFFMANN LA ROCHE | 2011-08-31 | — | — | CN | disclosed |
| CN-101316818-A | 3-amino-1-arylpropyl indoles and aza-substituted indoles | HOFFMANN LA ROCHE (CH) | 2008-12-03 | — | — | CN | disclosed |