Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYCS | P99999 | 3/20 | 0.49 |
| ▸ | TOP1 | P11387 | 3/20 | 0.48 |
| ▸ | STAT3 | P40763 | 1/20 | 0.48 |
| ▸ | STAT1 | P42224 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 2/20 | 0.35 |
| ▸ | SGK1 | O00141 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL140681 | 0.83 | TOP1 (0.67) | CYCSTOP1STAT3STAT1KDM4E | |
| SCHEMBL28919688 | 0.82 | TOP1 (0.65) | CYCSTOP1STAT3STAT1KDM4E | |
| SCHEMBL13504831 | 0.82 | STAT3 (0.42) | STAT3STAT1KDM4EALDH1A1HPGD | |
| SCHEMBL11334086 | 0.82 | TOP1 (0.65) | CYCSTOP1STAT3STAT1KDM4E | |
| SCHEMBL29090785 | 0.81 | EGFR (0.49) | CYCSTOP1STAT3STAT1KDM4E | |
| SCHEMBL17894094 | 0.81 | TOP1 (0.75) | CYCSTOP1STAT3STAT1KDM4E | |
| SCHEMBL22332272 | 0.81 | TOP1 (0.70) | CYCSTOP1STAT3STAT1KDM4E | |
| SCHEMBL11339474 | 0.78 | TOP1 (0.75) | CYCSTOP1STAT3STAT1KDM4E | |
| SCHEMBL22332236 | 0.78 | TOP1 (0.60) | CYCSTOP1STAT3STAT1KDM4E | |
| SCHEMBL12488803 | 0.77 | CYCS (0.78) | CYCSTOP1STAT3STAT1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150176-A1 | IMPLANTABLE CONCENTRATION SENSOR AND DEVICE | St. Jude Medical AB (SE) | 2010-02-10 | — | — | EP | claimed |
| WO-2008133551-A1 | IMPLANTABLE CONCENTRATION SENSOR AND DEVICE | ST. JUDE MEDICAL AB (SE) | 2008-11-06 | — | — | WO | claimed |
| EP-2114527-B1 | DEVICE AND METHOD OF A MEDICAL IMPLANT FOR MONITORING PROGRESSION OF HEART FAILURE IN A HUMAN HEART | ST JUDE MEDICAL (SE) | 2018-08-22 | — | — | EP | disclosed |
| EP-2150176-B1 | IMPLANTABLE CONCENTRATION SENSOR AND DEVICE | ST JUDE MEDICAL (SE) | 2016-04-27 | — | — | EP | disclosed |
| EP-2129433-B1 | IMPLANTABLE MEDICAL DEVICE COMPRISING AN OXYGEN SENSOR | ST JUDE MEDICAL (SE) | 2013-10-16 | — | — | EP | disclosed |
| US-20100185252-A1 | DEVICE AND METHOD OF A MEDICAL IMPLANT FOR MONITORING PROGRESSION OF HEART FAILURE IN A HUMAN HEART | ST. JUDE MEDICAL AB (SE) | 2010-07-22 | — | — | US | disclosed |
| US-20100130839-A1 | IMPLANTABLE DEVICES AND METHOD FOR DETERMINING A CONCENTRATION OF A SUBSTANCE AND/OR MOLECULE IN BLOOD OR TISSUE OF A PATIENT | ST. JUDE MEDICAL AB | 2010-05-27 | — | — | US | disclosed |
| EP-2150176-A1 | IMPLANTABLE CONCENTRATION SENSOR AND DEVICE | St. Jude Medical AB (SE) | 2010-02-10 | — | — | EP | disclosed |
| EP-2129433-A1 | IMPLANTABLE MEDICAL DEVICE COMPRISING AN OXYGEN SENSOR | St. Jude Medical AB (SE) | 2009-12-09 | — | — | EP | disclosed |
| EP-2114527-A1 | DEVICE AND METHOD OF A MEDICAL IMPLANT FOR MONITORING PROGRESSION OF HEART FAILURE IN A HUMAN HEART | St. Jude Medical AB (SE) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008133551-A1 | IMPLANTABLE CONCENTRATION SENSOR AND DEVICE | ST. JUDE MEDICAL AB (SE) | 2008-11-06 | — | — | WO | disclosed |
| WO-2008118047-A1 | IMPLANTABLE MEDICAL DEVICE COMPRISING AN OXYGEN SENSOR | ST. JUDE MEDICAL AB (SE) | 2008-10-02 | — | — | WO | disclosed |
| WO-2008105698-A1 | DEVICE AND METHOD OF A MEDICAL IMPLANT FOR MONITORING PROGRESSION OF HEART FAILURE IN A HUMAN HEART | ST. JUDE MEDICAL AB (SE) | 2008-09-04 | — | — | WO | disclosed |