Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAT2A | P31153 | 1/20 | 0.30 |
| ▸ | HTR7 | P34969 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27735512 | 0.87 | NR3C2 (0.33) | HSD11B1NR3C2LMNAMAPT | |
| SCHEMBL27756131 | 0.71 | NR3C2 (0.36) | HSD11B1NR3C2LMNAMAPTALDH1A1 | |
| SCHEMBL27862262 | 0.71 | NR3C2 (0.33) | NR3C2 | |
| SCHEMBL755954 | 0.71 | NR3C2 (0.46) | KCNH2NR3C2 | |
| SCHEMBL27735481 | 0.67 | NR3C2 (0.33) | HSD11B1NR3C2LMNAMAPTALDH1A1 | |
| SCHEMBL28775357 | 0.66 | HTR2C (0.33) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL27756110 | 0.66 | ALDH1A1 (0.33) | HSD11B1SMN1; SMN2LMNAMAPTALDH1A1 | |
| SCHEMBL27756113 | 0.62 | ALDH1A1 (0.32) | SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL27735498 | 0.62 | HSD11B1 (0.34) | HSD11B1 | |
| Propionaldehyde SCHEMBL28014512 | 0.57 | MAPT (0.44) | KCNH2SMN1; SMN2LMNAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101379048-A | Benzo oxazines and related nitrogen-containing heterobicyclic compounds useful as mineralocorticoid receptor modulating agents | MITSUBISHI TANABE PHARMA CORP (JP) | 2009-03-04 | — | — | CN | disclosed |