Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1493731 | 0.90 | POLB (0.60) | POLBSMN1; SMN2ALDH1A1LMNANPC1 | |
| SCHEMBL27765092 | 0.73 | ATM (0.42) | POLBSMN1; SMN2ALDH1A1TDP1KMT2A | |
| SCHEMBL1493809 | 0.73 | GAA (0.49) | POLBSMN1; SMN2ALDH1A1LMNARAB9A | |
| SCHEMBL28540250 | 0.70 | KDM4E (0.43) | SMN1; SMN2ALDH1A1TDP1HTTKMT2A | |
| SCHEMBL9243189 | 0.69 | ALOX15 (0.47) | POLBSMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL20346316 | 0.69 | SMN1; SMN2 (0.97) | POLBSMN1; SMN2ALDH1A1LMNANPC1 | |
| SCHEMBL1493744 | 0.69 | DPP4 (0.51) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL9617817 | 0.69 | PARL (0.41) | SMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL28659206 | 0.68 | ALOX15 (0.45) | POLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL9243186 | 0.68 | ENPP3 (0.43) | SMN1; SMN2ALDH1A1TDP1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101395131-B | Method for producing aminoacetylpyrrolidinecarbonitrile derivative and production intermediate thereof | KYORIN SEIYAKU KK | 2012-11-14 | — | — | CN | disclosed |
| CN-101395131-A | Method for producing aminoacetylpyrrolidinecarbonitrile derivative and production intermediate thereof | KYORIN SEIYAKU KK (JP) | 2009-03-25 | — | — | CN | disclosed |