Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 3/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | UBE2N | P61088 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2776754 | 0.79 | PNMT (0.42) | PNMTADRA2AADRA2BADRA2CSMN1; SMN2 | |
| SCHEMBL2776785 | 0.77 | PNMT (0.43) | PNMTADRA2AADRA2BADRA2CALDH1A1 | |
| SCHEMBL27778252 | 0.73 | PNMT (0.36) | PNMTADRA2AADRA2BADRA2CALDH1A1 | |
| SCHEMBL27799221 | 0.68 | PABPC1 (0.33) | SMN1; SMN2KDM4E | |
| SCHEMBL10180113 | 0.67 | ADRA2A (0.44) | PNMTADRA2AADRA2BADRA2CALDH1A1 | |
| SCHEMBL13547903 | 0.66 | PNMT (0.42) | PNMTADRA2AADRA2BADRA2CSMN1; SMN2 | |
| SCHEMBL2675271 | 0.65 | KIF11 (0.42) | PNMTADRA2AALDH1A1 | |
| SCHEMBL2675517 | 0.65 | ADRA2A (0.39) | PNMTADRA2ARAD52SMN1; SMN2ALDH1A1 | |
| SCHEMBL2778779 | 0.65 | PNMT (0.46) | PNMTADRA2AADRA2BADRA2CSMN1; SMN2 | |
| Bicarbonate SCHEMBL8143271 | 0.64 | MAPK1 (0.40) | PNMTADRA2AADRA2BADRA2CSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139886-A1 | QUINOLONE AND TETRAHYDROQUINOLINE AND RELATED COMPOUNDS HAVING NOS INHIBITORY ACTIVITY | Neuraxon Inc. (CA) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008116308-A1 | QUINOLONE AND TETRAHYDROQUINOLINE AND RELATED COMPOUNDS HAVING NOS INHIBITORY ACTIVITY | NEURAXON, INC. (CA) | 2008-10-02 | — | — | WO | disclosed |