Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 2/20 | 0.32 |
| ▸ | HTR6 | P50406 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.31 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.31 |
| ▸ | GPR3 | P46089 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29243638 | 0.77 | AADAT (0.38) | HRH1POLBNOTUMHDAC4HDAC7 | |
| SCHEMBL14051069 | 0.73 | MTNR1A (0.38) | HRH1HTR6NOTUMHDAC4HDAC7 | |
| SCHEMBL27500006 | 0.70 | KDM4C (0.38) | HRH1HTR6NOTUMHDAC4HDAC7 | |
| SCHEMBL27716440 | 0.65 | MAPT (0.39) | — | |
| SCHEMBL14543698 | 0.65 | NOTUM (0.64) | NOTUMHTR2AHTTHTR1ADRD2 | |
| SCHEMBL28780260 | 0.64 | OPRM1 (0.37) | HTR6DRD2OPRM1DRD3OPRK1 | |
| SCHEMBL8264301 | 0.64 | CACNA1G (0.33) | NOTUMLMNAKDM4EOPRM1 | |
| SCHEMBL19194596 | 0.63 | CA2 (0.43) | NOTUMCYP1A2CYP2C9CYP2C19HTT | |
| SCHEMBL28119505 | 0.63 | SLC6A2 (0.54) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8261724 | 0.63 | CYP2C9 (0.40) | POLBLMNAMEN1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101605776-A | 4-imidazolyl-1, 2,3, 4-tetrahydroquinoline derivatives and their use as aldosterone/11-beta-hydroxylase inhibitors | NOVARTIS AG (CH) | 2009-12-16 | — | — | CN | disclosed |