Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 2/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27785975 | 0.88 | GABRA1 (0.34) | GABRG2GABRB3GABRA2GABRA1GABRA5 | |
| SCHEMBL27807933 | 0.87 | GABRA1 (0.45) | GABRG2GABRB3GABRA2GABRA1GABRA5 | |
| SCHEMBL27807907 | 0.84 | ALK (0.35) | GABRG2GABRB3GABRA2GABRA1GABRA5 | |
| SCHEMBL27807964 | 0.81 | HRH4 (0.35) | GABRG2GABRB3GABRA2LRRK2 | |
| SCHEMBL27807918 | 0.78 | LCK (0.47) | — | |
| SCHEMBL27807945 | 0.77 | HRH4 (0.39) | — | |
| SCHEMBL27807917 | 0.76 | GABRG2 (0.36) | GABRG2GABRB3GABRA2GABRA1GABRA5 | |
| SCHEMBL27785935 | 0.75 | MAPK1 (0.31) | ADORA2A | |
| SCHEMBL27785965 | 0.75 | — | — | |
| SCHEMBL27785937 | 0.74 | ADORA2A (0.32) | ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101778849-A | Fused quinoline derivatives useful as gaba modulators | ASTRAZENECA AB | 2010-07-14 | — | — | CN | claimed |
| CN-101778849-A | Fused quinoline derivatives useful as gaba modulators | ASTRAZENECA AB | 2010-07-14 | — | — | CN | disclosed |