Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 1/20 | 0.56 |
| ▸ | HTR3A | P46098 | 1/20 | 0.50 |
| ▸ | AGXT | P21549 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.43 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.43 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17803140 | 0.85 | MEN1 (0.49) | AGXTDRD2KCNH2FAAHNPC1 | |
| SCHEMBL5210514 | 0.81 | GAA (0.52) | ADRA2CHTR3ADRD2NPC1MAPT | |
| SCHEMBL27756289 | 0.81 | KMO (0.53) | AGXTFAAHNPC1MAPTMEN1 | |
| SCHEMBL1372927 | 0.80 | KCNH2 (0.69) | ADRA2CHTR3AAGXTDRD2KCNH2 | |
| SCHEMBL12968842 | 0.77 | ADRA2C (0.56) | ADRA2CHTR3AAGXTDRD2KCNH2 | |
| SCHEMBL29554265 | 0.77 | ADRA2C (0.59) | ADRA2CHTR3AAGXTDRD2NPC1 | |
| SCHEMBL2557935 | 0.77 | ADRA2C (0.59) | ADRA2CHTR3AAGXTDRD2NPC1 | |
| SCHEMBL2599616 | 0.77 | ADRA2C (0.59) | ADRA2CHTR3AAGXTDRD2KCNH2 | |
| SCHEMBL25492995 | 0.75 | ADRA2C (0.57) | ADRA2CHTR3AAGXTDRD2KCNH2 | |
| SCHEMBL3592917 | 0.75 | ADRA2C (0.57) | ADRA2CHTR3AAGXTDRD2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101888877-A | Pyridine derivatives for the treatment of amyloid-related diseases | SENEXIS LTD | 2010-11-17 | — | — | CN | disclosed |