Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.51 |
| ▸ | TRPM8 | Q7Z2W7 | 8/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14631947 | 0.88 | KDM4E (0.43) | ALOX5TRPM8KDM4EMEN1MAPT | |
| SCHEMBL27803393 | 0.86 | ALOX5 (0.52) | ALOX5TRPM8KDM4EPTGS2SMN1; SMN2 | |
| SCHEMBL27899608 | 0.86 | ALOX5 (0.52) | ALOX5TRPM8PTGS2 | |
| SCHEMBL27803421 | 0.85 | ALOX5 (0.51) | ALOX5TRPM8KDM4EKMT2APTGS2 | |
| SCHEMBL27837166 | 0.84 | RORB (0.49) | ALOX5KDM4EMEN1MAPTKMT2A | |
| SCHEMBL27803545 | 0.84 | ALOX5 (0.52) | ALOX5KDM4EMAPTPTGS2ALDH1A1 | |
| SCHEMBL27626587 | 0.84 | ALOX5 (0.71) | ALOX5KDM4EMEN1MAPTKMT2A | |
| SCHEMBL27803408 | 0.81 | ALOX5 (0.47) | ALOX5TRPM8KDM4EPTGS2ALDH1A1 | |
| SCHEMBL27817817 | 0.79 | ALDH1A1 (0.49) | ALOX5KDM4EMEN1MAPTKMT2A | |
| SCHEMBL496405 | 0.77 | KDM4E (0.71) | TRPM8KDM4EMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102164896-A | Phenethylamide derivatives and their heterocyclic analogues | ACTELION PHARMACEUTICALS LTD | 2011-08-24 | — | — | CN | disclosed |
| CN-101965343-A | 2-aza-bicyclo[2.2.1]heptane derivatives | ACTELION PHARMACEUTICALS LTD | 2011-02-02 | — | — | CN | disclosed |