Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | FBP1 | P09467 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27824237 | 0.88 | ALOX5 (0.51) | KDM4EMAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14632056 | 0.84 | ALDH1A1 (0.56) | KDM4EMAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14631918 | 0.84 | RORB (0.46) | KDM4EMAPTKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL14632067 | 0.84 | TRPM8 (0.44) | KDM4ESMN1; SMN2TRPM8ALOX5KMO | |
| SCHEMBL14631930 | 0.84 | ALDH1A1 (0.45) | KDM4EMAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14632053 | 0.83 | FBP1 (0.44) | KDM4EMAPTSMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL14631939 | 0.82 | FBP1 (0.53) | KDM4EMAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL496186 | 0.80 | PIN1 (0.53) | KDM4EMAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL27824238 | 0.76 | KDM4E (0.52) | KDM4EMAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL18060545 | 0.76 | CYP1A2 (0.50) | KDM4EMAPTMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188282-B1 | 1,2-DIAMIDO-ETHYLENE DERIVATIVES AS OREXIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-01-23 | — | — | EP | claimed |