Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | CTSL | P07711 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | FAAH | O00519 | 2/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | APAF1 | O14727 | 1/20 | 0.41 |
| ▸ | TDP2 | O95551 | 1/20 | 0.41 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11608129 | 0.82 | HSD17B10 (0.59) | HSD17B10ALDH1A1CTSLLMNAFAAH | |
| SCHEMBL27797797 | 0.81 | CTSL (0.42) | HSD17B10ALDH1A1CTSLLMNAFAAH | |
| SCHEMBL3645705 | 0.78 | ALDH1A1 (0.44) | HSD17B10ALDH1A1CTSLLMNAFAAH | |
| SCHEMBL10604253 | 0.75 | ADRB2 (0.55) | HSD17B10ALDH1A1CTSLLMNAFAAH | |
| SCHEMBL10607221 | 0.74 | ADRB2 (0.57) | HSD17B10ALDH1A1CTSLLMNAFAAH | |
| SCHEMBL5585773 | 0.74 | CTSK (0.48) | HSD17B10ALDH1A1CTSLLMNAFAAH | |
| SCHEMBL11609600 | 0.73 | ALDH1A1 (0.54) | HSD17B10ALDH1A1CTSLFAAHCTSK | |
| SCHEMBL10604425 | 0.72 | ADRB2 (0.52) | HSD17B10CTSLLMNAFAAHCTSK | |
| SCHEMBL1976429 | 0.72 | ALDH1A1 (0.47) | HSD17B10ALDH1A1CTSLLMNAFAAH | |
| SCHEMBL10604536 | 0.72 | CTSL (0.49) | HSD17B10ALDH1A1CTSLLMNAFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102344457-B | Spirocyclic aminoquinolones as GSK-3 inhibitors | KYORIN SEIYAKU KK | 2015-07-22 | — | — | CN | disclosed |
| CN-102344457-A | Spirocyclic aminoquinolones as gsk-3 inhibitors | KYORIN SEIYAKU KK | 2012-02-08 | — | — | CN | disclosed |
| CN-101855229-A | Spirocyclic aminoquinolones as GSK-3 inhibitors | ACTIVX BIOSCIENCES INC | 2010-10-06 | — | — | CN | disclosed |