Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 1/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | APAF1 | O14727 | 1/20 | 0.43 |
| ▸ | TDP2 | O95551 | 1/20 | 0.43 |
| ▸ | NSD2 | O96028 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | GALK1 | P51570 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.43 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3645705 | 0.95 | ALDH1A1 (0.44) | CTSKADRB2CTSLALDH1A1HTT | |
| SCHEMBL5586066 | 0.85 | ALDH1A1 (0.45) | CTSKCTSLALDH1A1HTTKDM4E | |
| SCHEMBL9009913 | 0.79 | RAB9A (0.45) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL27797797 | 0.77 | CTSL (0.42) | CTSKADRB2CTSLALDH1A1HTT | |
| SCHEMBL9009877 | 0.77 | ALDH1A1 (0.51) | ALDH1A1HTTKDM4EMEN1KMT2A | |
| SCHEMBL27743186 | 0.77 | KMT2A (0.41) | CTSLALDH1A1HTTKDM4EMEN1 | |
| SCHEMBL27712467 | 0.76 | IDO1 (0.42) | CTSKCTSLMEN1KMT2AMAPT | |
| SCHEMBL10590807 | 0.76 | CTSK (0.54) | CTSKADRB2CTSLALDH1A1HTT | |
| SCHEMBL11609600 | 0.76 | ALDH1A1 (0.54) | CTSKADRB2CTSLALDH1A1HTT | |
| SCHEMBL9009859 | 0.75 | HTT (0.37) | ALDH1A1HTTMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1976932-A | Fused quinoline derivative and use thereof | TAKEDA PHARMACEUTICAL (JP) | 2007-06-06 | — | — | CN | disclosed |
| EP-1740584-A1 | FUSED QUINOLINE DERIVATIVE AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005105802-A1 | FUSED QUINOLINE DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-11-10 | — | — | WO | disclosed |