Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1829193 | 0.83 | LMNA (0.58) | KDM4ERAB9ASMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL16456582 | 0.72 | MAPK14 (0.43) | KDM4EALDH1A1MAPTPOLBLMNA | |
| SCHEMBL2787427 | 0.71 | STIM1 (0.48) | KDM4ERAB9ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL16810760 | 0.70 | MAPT (0.47) | KDM4ERAB9ASMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL16456523 | 0.70 | PORCN (0.52) | RAB9AMEN1KMT2APORCNNPC1 | |
| SCHEMBL2785129 | 0.69 | MAPT (0.41) | RAB9ASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL17644787 | 0.69 | IL2 (0.59) | RAB9ASMN1; SMN2MAPTLMNANPC1 | |
| SCHEMBL8297617 | 0.68 | RAB9A (0.51) | KDM4ERAB9ASMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL16456528 | 0.68 | ABL1 (0.42) | PORCN | |
| SCHEMBL16456595 | 0.68 | MAPK14 (0.37) | MEN1KMT2AMAPTPOLBPORCN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651232-B1 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP (US) | 2010-12-22 | — | — | EP | claimed |