Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | PPARG | P37231 | 4/20 | 0.47 |
| ▸ | PPARD | Q03181 | 4/20 | 0.47 |
| ▸ | PPARA | Q07869 | 4/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28765765 | 0.90 | ALDH1A1 (0.56) | ALDH1A1MAPTMEN1KMT2ACYP1A2 | |
| SCHEMBL27706390 | 0.85 | MAPT (0.56) | ALDH1A1MAPTMEN1KMT2ACYP1A2 | |
| SCHEMBL4689814 | 0.78 | GRN (0.64) | MAPTMEN1KMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL28767211 | 0.78 | GRN (0.61) | MAPTMEN1KMT2ACYP1A2MAPK1 | |
| SCHEMBL27706437 | 0.77 | SMN1; SMN2 (0.63) | ALDH1A1MAPTMEN1KMT2ACYP1A2 | |
| SCHEMBL27694051 | 0.75 | LMNA (0.53) | ALDH1A1MAPTMEN1KMT2ACYP1A2 | |
| SCHEMBL14144797 | 0.72 | SMN1; SMN2 (0.81) | ALDH1A1MAPTMEN1KMT2AMAPK1 | |
| SCHEMBL27687135 | 0.72 | MARS1 (0.65) | MAPTMEN1KMT2ACYP1A2MAPK1 | |
| SCHEMBL4690033 | 0.71 | PPARG (0.83) | PPARGPPARDPPARA | |
| SCHEMBL4692309 | 0.70 | PPARG (0.54) | MAPTMEN1KMT2ACYP2C9SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102266327-B | Application of 1-(4-tert-butyl benzyl)-3-(4-chlorphenyl)-1H-pyrazol-5-carbohydrazide in preparation of medicaments | UNIV SHANDONG | 2012-09-19 | — | — | CN | disclosed |
| CN-102266327-B | Application of 1-(4-tert-butyl benzyl)-3-(4-chlorphenyl)-1H-pyrazol-5-carbohydrazide in preparation of medicaments | UNIV SHANDONG | 2012-09-19 | — | — | CN | disclosed |
| CN-102266327-A | Application of 1-(4-tert-butyl benzyl)-3-(4-chlorphenyl)-1H-pyrazol-5-carbohydrazide to preparation of medicaments | UNIV SHANDONG | 2011-12-07 | — | — | CN | disclosed |
| CN-102266327-A | Application of 1-(4-tert-butyl benzyl)-3-(4-chlorphenyl)-1H-pyrazol-5-carbohydrazide to preparation of medicaments | UNIV SHANDONG | 2011-12-07 | — | — | CN | disclosed |