Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 9/20 | 0.38 |
| ▸ | PPARA | Q07869 | 8/20 | 0.38 |
| ▸ | PPARD | Q03181 | 7/20 | 0.38 |
| ▸ | PHGDH | O43175 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.31 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.31 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.31 |
| ▸ | AHR | P35869 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28800067 | 0.85 | RORC (0.40) | PPARGPPARAPPARDRORC | |
| SCHEMBL27884298 | 0.83 | PPARG (0.36) | PPARGPPARAPPARDAKR1C3AKR1C2 | |
| SCHEMBL28800079 | 0.83 | PPARG (0.36) | PPARGPPARAPPARDPHGDHRORC | |
| SCHEMBL28946335 | 0.83 | PPARG (0.36) | PPARGPPARAPPARDRORC | |
| SCHEMBL27867734 | 0.83 | CCR2 (0.39) | PPARGPPARAPPARDRORC | |
| SCHEMBL28800059 | 0.83 | PPARG (0.36) | PPARGPPARAPPARDRORC | |
| SCHEMBL28807362 | 0.82 | PPARG (0.39) | PPARGPPARAPPARDTP53MAPT | |
| SCHEMBL12096981 | 0.81 | PPARG (0.57) | PPARGPPARAPPARDPHGDHRORC | |
| SCHEMBL27867762 | 0.79 | PPARG (0.41) | PPARGPPARAPPARDRORC | |
| SCHEMBL27833812 | 0.78 | PPARG (0.56) | PPARGPPARAPPARDRORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103554006-A | Use of indole derivatives as nurr-1 activators for the application thereof as a medicament for the treatment of parkinson's disease | FOURNIER LAB SA | 2014-02-05 | — | — | CN | disclosed |
| CN-102596906-A | Use of indole derivatives as NURR-1 activators as agents for the treatment of Parkinson's disease | FOURNIER LAB SA | 2012-07-18 | — | — | CN | disclosed |