SCHEMBL2789622

SCHEMBL2789622

NN(C(=O)C1=CN(c2ccccc2)C=CC1)c1ccccc1

nearest known ligand 0.39

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 1/20 0.33
CHRM4 P08173 2/20 0.33
CHRM3 P20309 2/20 0.33
ATR Q13535 1/20 0.32
ADRA2C P18825 1/20 0.31
CHRM5 P08912 1/20 0.30
CHRM1 P11229 1/20 0.30
ALDH1A1 P00352 2/20 0.30
POLB P06746 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21753524 0.80 ALDH1A1 (0.38) NPSR1ALDH1A1POLBSMN1; SMN2
SCHEMBL27854950 0.75 ADRA2C (0.35) NPSR1ADRA2CALDH1A1SMN1; SMN2
SCHEMBL11869460 0.71 CYP3A4 (0.33) ALDH1A1SMN1; SMN2
SCHEMBL9769555 0.70 NPSR1 (0.52) NPSR1ATRADRA2CALDH1A1POLB
SCHEMBL27854997 0.70 ALDH1A1 (0.40) NPSR1CHRM3ALDH1A1POLBSMN1; SMN2
SCHEMBL22092555 0.67 LDHA (0.33) NPSR1ALDH1A1
SCHEMBL5868364 0.66 ALDH1A1 (0.54) NPSR1ALDH1A1
SCHEMBL21753518 0.66 MAPK1 (0.35) NPSR1ALDH1A1SMN1; SMN2
SCHEMBL21753502 0.66 ALDH1A1 (0.35) ALDH1A1SMN1; SMN2
SCHEMBL9769553 0.66 ALDH1A1 (0.58) NPSR1ALDH1A1POLBSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010128528-A2 NOVEL HETEROCYCLIC COMPOUNDS TORRENT PHARMACEUTICALS LIMITED (IN) 2010-11-11 WO disclosed