Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22092555 | 0.85 | LDHA (0.33) | ALDH1A1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL21753518 | 0.84 | MAPK1 (0.35) | ALDH1A1KDM4EKMT2AMEN1HPGD | |
| SCHEMBL21753502 | 0.84 | ALDH1A1 (0.35) | ALDH1A1KDM4EHPGDMAPTLMNA | |
| SCHEMBL860052 | 0.82 | PARP1 (0.44) | ALDH1A1RIPK2PARP1L3MBTL1LMNA | |
| SCHEMBL2789622 | 0.80 | NPSR1 (0.33) | ALDH1A1POLBSMN1; SMN2NPSR1 | |
| SCHEMBL28854513 | 0.80 | CA12 (0.38) | ALDH1A1KDM4EKMT2AMEN1HPGD | |
| SCHEMBL21891257 | 0.80 | ALDH1A1 (0.45) | ALDH1A1KMT2AMEN1PARP1MAPT | |
| SCHEMBL21753516 | 0.80 | TSHR (0.40) | ALDH1A1KDM4EKMT2AHSD17B10MEN1 | |
| SCHEMBL11869460 | 0.74 | CYP3A4 (0.33) | ALDH1A1KMT2AHSD17B10MEN1HPGD | |
| SCHEMBL7865053 | 0.73 | OPRD1 (0.40) | ALDH1A1KDM4EKMT2AMEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12618050-B2 | Engineered polypeptides that exhibit increased catalytic efficiency for unnatural cofactors and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2026-05-05 | — | — | US | claimed |
| WO-2025245512-A1 | METHODS TO SHIFT REDOX EQUILIBRIUM USING AN ORTHOGONAL REDOX COFACTOR, AND APPLICATIONS THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2025-11-27 | — | — | WO | claimed |
| US-20230322857-A1 | RECOMBINANTLY ENGINEERED POLYPEPTIDES CAPABLE OF RECYCLING NONCANONICAL COFACTORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2023-10-12 | — | — | US | claimed |
| US-20220090027-A1 | ENGINEERED POLYPEPTIDES THAT EXHIBIT INCREASED CATALYTIC EFFICIENCY FOR UNNATURAL COFACTORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2022-03-24 | — | — | US | claimed |
| WO-2020123563-A1 | ENGINEERED POLYPEPTIDES THAT EXHIBIT INCREASED CATALYTIC EFFICIENCY FOR UNNATURAL COFACTORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-06-18 | — | — | WO | claimed |
| US-12618050-B2 | Engineered polypeptides that exhibit increased catalytic efficiency for unnatural cofactors and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2026-05-05 | — | — | US | disclosed |
| WO-2025245512-A1 | METHODS TO SHIFT REDOX EQUILIBRIUM USING AN ORTHOGONAL REDOX COFACTOR, AND APPLICATIONS THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2025-11-27 | — | — | WO | disclosed |
| WO-2024098042-A2 | GROWTH-BASED SELECTION PLATFORM FOR NONCANONICAL COFACTOR OXIDIZING ENZYMES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2024-05-10 | — | — | WO | disclosed |
| US-20230322857-A1 | RECOMBINANTLY ENGINEERED POLYPEPTIDES CAPABLE OF RECYCLING NONCANONICAL COFACTORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2023-10-12 | — | — | US | disclosed |
| US-20220090027-A1 | ENGINEERED POLYPEPTIDES THAT EXHIBIT INCREASED CATALYTIC EFFICIENCY FOR UNNATURAL COFACTORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2022-03-24 | — | — | US | disclosed |
| WO-2020123563-A1 | ENGINEERED POLYPEPTIDES THAT EXHIBIT INCREASED CATALYTIC EFFICIENCY FOR UNNATURAL COFACTORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-06-18 | — | — | WO | disclosed |
| WO-2020038460-A1 | NOVEL QUINOLINE DERIVATIVE INHIBITOR | 南京药捷安康生物科技有限公司 | 2020-02-27 | — | — | WO | disclosed |
| CN-104185627-B | Pyridone Derivatives | 第三共株式会社 | 2018-01-12 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12618050-B2 | Engineered polypeptides that exhibit increased catalytic efficiency for unnatural cofactors and uses thereof | NNMT, NAPRT, NQO1 | ALDH1A1 754/4885KDM4E 1913/4885KMT2A 359/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.