Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 4/20 | 0.36 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10388908 | 0.87 | KDM4E (0.44) | PRCPGSK3BPDE10AKDM4EALDH1A1 | |
| SCHEMBL19049065 | 0.77 | HTR2C (0.39) | MAPTGSK3BPDE10AALDH1A1 | |
| SCHEMBL19875603 | 0.76 | ROCK2 (0.45) | — | |
| Hydrochloric Acid SCHEMBL19875629 | 0.75 | MAPK1 (0.47) | — | |
| SCHEMBL28597182 | 0.74 | ADRB1 (0.45) | PRCPMAPTGSK3BPDE10AALDH1A1 | |
| SCHEMBL26601226 | 0.73 | CYP2D6 (0.41) | MAPTNPSR1KDM4EALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL19875595 | 0.72 | GSK3B (0.37) | GSK3BPDE10ARPS6KB1 | |
| SCHEMBL27985677 | 0.72 | — | — | |
| SCHEMBL27948360 | 0.71 | GSK3B (0.44) | GSK3B | |
| SCHEMBL16994753 | 0.71 | MAP1LC3B (0.41) | MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102892758-A | Pyridine and pyrazine derivatives for the treatment of CF | NOVARTIS AG | 2013-01-23 | — | — | CN | disclosed |