Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | NPY1R | P25929 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | NNMT | P40261 | 1/20 | 0.38 |
| ▸ | CCR2 | P41597 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | GPR183 | P32249 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3662100 | 0.92 | LMNA (0.43) | ALDH1A1LMNAKCNH2NPY1RSLC6A4 | |
| SCHEMBL23112352 | 0.89 | NNMT (0.42) | ALDH1A1LMNAKCNH2NNMTCCR2 | |
| SCHEMBL3469434 | 0.84 | GPR119 (0.48) | — | |
| SCHEMBL5468647 | 0.80 | MAPT (0.47) | ALDH1A1LMNAKCNH2CCR2CYP2D6 | |
| SCHEMBL3024794 | 0.79 | GPR119 (0.53) | ALDH1A1LMNACCR2 | |
| SCHEMBL23647652 | 0.79 | NNMT (0.43) | ALDH1A1LMNAKCNH2NPY1RSLC6A4 | |
| SCHEMBL29457438 | 0.78 | GPR119 (0.47) | CCR2MEN1KMT2A | |
| SCHEMBL27210984 | 0.78 | GPR119 (0.47) | CCR2MEN1KMT2A | |
| SCHEMBL5462315 | 0.78 | GHSR (0.44) | ALDH1A1LMNACYP2D6HPGDMEN1 | |
| SCHEMBL2264503 | 0.77 | HDAC3 (0.48) | GRIN2BSCN9ACYP2D6MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010051245-A1 | BENZIMIDAZOLE AND AZA-BENZIMIDAZOLE CARBOXAMIDES | MERCK SHARP & DOHME CORP. (US) | 2010-05-06 | — | — | WO | disclosed |