Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | GPR183 | P32249 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 2/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2790975 | 0.89 | ALDH1A1 (0.40) | NNMTGRIN2BSCN9AALDH1A1GPR183 | |
| SCHEMBL3662100 | 0.86 | LMNA (0.43) | NNMTGRIN2BALDH1A1KMT2AMEN1 | |
| SCHEMBL28548511 | 0.83 | GPR119 (0.49) | NNMTALDH1A1POLBBACE1HTT | |
| SCHEMBL29977161 | 0.83 | GPR119 (0.49) | NNMTALDH1A1POLBBACE1HTT | |
| SCHEMBL23112901 | 0.79 | NNMT (0.37) | NNMTSCN9AMKNK1MKNK2ALDH1A1 | |
| SCHEMBL23112557 | 0.79 | OPRD1 (0.39) | NNMTGRIN2BSCN9AGPR183KMT2A | |
| SCHEMBL16874757 | 0.77 | OPRM1 (0.48) | GRIN2BALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL3469434 | 0.76 | GPR119 (0.48) | BACE1 | |
| SCHEMBL23231746 | 0.75 | NNMT (0.41) | NNMTSCN9AMKNK1MKNK2ALDH1A1 | |
| SCHEMBL23647652 | 0.75 | NNMT (0.43) | NNMTMKNK1MKNK2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3793559-A1 | SUBSTITUTED DIHYDROPYRAZOLO PYRAZINE CARBOXAMIDE DERIVATIVES | Bayer Aktiengesellschaft (DE) | 2021-03-24 | — | — | EP | disclosed |