Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PI4KA | P42356 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23620906 | 0.89 | HRH3 (0.46) | POLBHCAR3AOC3HRH3PKM | |
| SCHEMBL29449725 | 0.89 | HRH3 (0.46) | POLBHCAR3AOC3HRH3PKM | |
| SCHEMBL23620903 | 0.85 | HRH3 (0.44) | POLBHCAR3AOC3HRH3PKM | |
| SCHEMBL3313839 | 0.84 | HRH3 (0.54) | POLBHCAR3EGFRAOC3HRH3 | |
| SCHEMBL30380846 | 0.84 | HRH3 (0.54) | POLBHCAR3EGFRAOC3HRH3 | |
| SCHEMBL2793987 | 0.84 | HCAR3 (0.57) | POLBHCAR3AOC3HRH3PKM | |
| SCHEMBL23634036 | 0.84 | HRH3 (0.42) | POLBHCAR3AOC3HRH3PKM | |
| SCHEMBL94034 | 0.81 | HCAR3 (0.40) | POLBHCAR3EGFRAOC3ADRA2A | |
| SCHEMBL23634074 | 0.81 | ALDH1A1 (0.41) | POLBHCAR3TRPV1AOC3HRH3 | |
| SCHEMBL7245666 | 0.81 | HRH3 (0.44) | POLBHCAR3AOC3HRH3PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963313-B1 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE (DGAT) | MADRIGAL PHARMACEUTICALS INC (US) | 2012-11-14 | — | — | EP | claimed |
| EP-1963313-A2 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE (DGAT) | F.HOFFMANN-LA ROCHE AG (CH) | 2008-09-03 | — | — | EP | claimed |
| WO-2007060140-A2 | INHIBITORS OF DIACYGLYCEROL ACYLTRANSFERASE (DGAT) | F. HOFFMANN-LA ROCHE AG (CH) | 2007-05-31 | — | — | WO | claimed |
| EP-4177246-A1 | FUSED OXAZEPINES AS INHIBITORS OF PEROXIREDOXINS | Centro Atlántico del Medicamento, SA (ES) | 2023-05-10 | — | — | EP | disclosed |
| EP-4177246-A1 | FUSED OXAZEPINES AS INHIBITORS OF PEROXIREDOXINS | Centro Atlántico del Medicamento, SA (ES) | 2023-05-10 | — | — | EP | disclosed |
| CN-110383156-B | Liquid crystal aligning agent, application thereof, liquid crystal element and polymer | JSR株式会社 | 2022-09-13 | — | — | CN | disclosed |
| CN-110291455-B | Liquid crystal aligning agent, liquid crystal alignment film and method for producing the same, liquid crystal element and polymer | JSR株式会社 | 2022-03-22 | — | — | CN | disclosed |
| US-10752624-B2 | Kinase inhibitors | ORIGENIS GMBH (DE) | 2020-08-25 | — | — | US | disclosed |
| CN-111171842-A | Liquid crystal aligning agent, liquid crystal alignment film, liquid crystal element and polymer | JSR株式会社 | 2020-05-19 | — | — | CN | disclosed |
| US-20180305356-A1 | NOVEL KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2018-10-25 | — | — | US | disclosed |
| US-10000482-B2 | Kinase inhibitors | ORIGENIS GMBH (DE) | 2018-06-19 | — | — | US | disclosed |
| US-20100056524-A1 | Compound | MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) | 2010-03-04 | — | — | US | disclosed |
| WO-2009122180-A1 | PYRIMIDINE DERIVATIVES CAPABLE OF INHIBITING ONE OR MORE KINASES | MEDICAL RESEARCH COUNCIL (GB) | 2009-10-08 | — | — | WO | disclosed |
| CN-101316844-A | Inhibitors of diacylglycerol acyltransferase (DGAT) | HOFFMANN LA ROCHE (CH) | 2008-12-03 | — | — | CN | disclosed |
| EP-1963313-A2 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE (DGAT) | F.HOFFMANN-LA ROCHE AG (CH) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007060140-A2 | INHIBITORS OF DIACYGLYCEROL ACYLTRANSFERASE (DGAT) | F. HOFFMANN-LA ROCHE AG (CH) | 2007-05-31 | — | — | WO | disclosed |
| WO-2007060140-A2 | INHIBITORS OF DIACYGLYCEROL ACYLTRANSFERASE (DGAT) | F. HOFFMANN-LA ROCHE AG (CH) | 2007-05-31 | — | — | WO | disclosed |
| US-20070123504-A1 | Diacylglycerol acyltransferase inhibitors | MADRIGAL PHARMACEUTICALS, INC. | 2007-05-31 | — | — | US | disclosed |
| US-20070123504-A1 | Diacylglycerol acyltransferase inhibitors | MADRIGAL PHARMACEUTICALS, INC. | 2007-05-31 | — | — | US | disclosed |
| US-20070123504-A1 | Diacylglycerol acyltransferase inhibitors | MADRIGAL PHARMACEUTICALS, INC. | 2007-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056524-A1 | Compound | NR3C2, NR3C1, NR2E3 | POLB 4178/4885HCAR3 175/4885TRPV1 2644/4885 |
| US-20180305356-A1 | NOVEL KINASE INHIBITORS | LRRK2, MYLK2, MYLK | POLB 3335/4885HCAR3 4326/4885TRPV1 2589/4885 |
| US-20070123504-A1 | Diacylglycerol acyltransferase inhibitors | DGAT2, DGAT1, LCAT | POLB 3563/4885HCAR3 3114/4885TRPV1 2202/4885 |
| US-10000482-B2 | Kinase inhibitors | LRRK2, MYLK2, MYLK | POLB 3175/4885HCAR3 4006/4885TRPV1 2529/4885 |
| US-10752624-B2 | Kinase inhibitors | LRRK2, MYLK2, MYLK | POLB 3175/4885HCAR3 4006/4885TRPV1 2529/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.