Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5C | P41229 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 3/20 | 0.35 |
| ▸ | PPARA | Q07869 | 3/20 | 0.35 |
| ▸ | PPARD | Q03181 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27915879 | 0.83 | P2RX7 (0.34) | KDM5CKDM4CKMT2AMAPK1 | |
| SCHEMBL27666299 | 0.81 | KDM4E (0.55) | KDM4EALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL17155190 | 0.81 | KDM5C (0.40) | KDM5CKDM4CKDM4EALDH1A1NPSR1 | |
| SCHEMBL4285303 | 0.81 | TBK1 (0.47) | KDM4EALDH1A1POLB | |
| SCHEMBL28289064 | 0.79 | MGLL (0.40) | KDM4EALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL28055968 | 0.78 | ALDH1A1 (0.41) | KDM4EALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL28024936 | 0.77 | LMNA (0.53) | KDM4EALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL27934411 | 0.77 | NR1H2 (0.41) | KDM4EALDH1A1NPSR1MAPTGFER | |
| SCHEMBL27915910 | 0.77 | L3MBTL1 (0.40) | L3MBTL1POLBLMNA | |
| SCHEMBL27934437 | 0.77 | KMT2A (0.44) | KDM4EALDH1A1NPSR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101981036-B | Pyrrolo [2, 3-D] pyridines and use thereof as tyrosine kinase inhibitors | NOVARTIS AG | 2013-09-04 | — | — | CN | disclosed |