Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.39 |
| ▸ | HTR6 | P50406 | 7/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 5/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | GHSR | Q92847 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27945952 | 0.79 | ALDH1A1 (0.39) | ALDH1A1TP53MAPTALOX12CES1 | |
| SCHEMBL5981551 | 0.67 | ALDH1A1 (0.47) | ALDH1A1TP53MAPTALOX12HTR6 | |
| SCHEMBL6180564 | 0.65 | ALDH1A1 (0.46) | ALDH1A1TP53MAPTALOX12HTR6 | |
| SCHEMBL733450 | 0.65 | ALDH1A1 (0.58) | ALDH1A1TP53MAPTALOX12HTR6 | |
| SCHEMBL3459900 | 0.65 | HTR6 (0.55) | ALDH1A1TP53MAPTHTR6DRD1 | |
| SCHEMBL128252 | 0.65 | HTR6 (0.51) | ALDH1A1TP53MAPTHTR6DRD1 | |
| SCHEMBL1770690 | 0.64 | LCAT (0.36) | AR | |
| SCHEMBL5982243 | 0.64 | KCNQ3 (0.46) | ALDH1A1TP53MAPTALOX12HTR6 | |
| SCHEMBL24898308 | 0.63 | POLB (0.34) | PDK2PKM | |
| SCHEMBL30211424 | 0.63 | POLB (0.34) | PDK2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103443076-B | Indol-2-one derivatives disubstituted in position 3, their preparation and their therapeutic application | 赛诺菲-安万特 | 2016-06-22 | — | — | CN | disclosed |
| CN-103443076-A | Indol-2-one derivatives disubstituted in position 3, their preparation and their therapeutic application | SANOFI AVENTIS | 2013-12-11 | — | — | CN | disclosed |