Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 3/20 | 0.41 |
| ▸ | FLT4 | P35916 | 3/20 | 0.41 |
| ▸ | KDR | P35968 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2795074 | 0.81 | TRPV4 (0.47) | ALDH1A1SMN1; SMN2MEN1KMT2ATRPV4 | |
| SCHEMBL28819794 | 0.79 | SMN1; SMN2 (0.57) | ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL1144066 | 0.77 | ALDH1A1 (0.69) | ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL29712843 | 0.77 | ALDH1A1 (0.69) | ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL5452555 | 0.77 | ABL1 (0.58) | ALDH1A1KDM4ESMN1; SMN2TRPV4FLT1 | |
| SCHEMBL6331423 | 0.75 | HSP90AB1 (0.67) | ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL11118433 | 0.75 | ALDH1A1 (0.50) | ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL8022080 | 0.74 | KCNH2 (0.49) | ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL16168328 | 0.74 | ALDH1A1 (0.61) | ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL29444021 | 0.74 | ALDH1A1 (0.49) | ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100168087-A1 | BENZO[1,2,3]THIADIAZINE DERIVATES | EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAG (HU) | 2010-07-01 | — | — | US | disclosed |
| EP-2061777-A1 | BENZOÝ1,2,3¨THIADIAZINE DERIVATIVES | Egis Gyogyszergyar Nyilvánosan Múködó Részvénytársaság (HU) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008020255-A1 | BENZO[1,2,3]THIADIAZINE DERIVATIVES | EGIS GYÓGYSZERGYÁR Nyilvánosan Müködö Részvénytársagág (HU) | 2008-02-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168087-A1 | BENZO[1,2,3]THIADIAZINE DERIVATES | SULT2A1, TPH1, CYP1A1 | ALDH1A1 39/4885KDM4E 3186/4885SMN1; SMN2 454/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.