Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 11/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28261342 | 0.89 | MEN1 (0.52) | MAPTRAB9ATDP1KMT2AMEN1 | |
| SCHEMBL28429490 | 0.88 | NR1H4 (0.45) | SMOMAPTMAPK1RAB9ASMN1; SMN2 | |
| SCHEMBL28426457 | 0.88 | CHRNB2 (0.43) | SMOSMN1; SMN2KMT2AMEN1LMNA | |
| SCHEMBL27972279 | 0.87 | FADS1 (0.39) | SMORAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL27972568 | 0.87 | MEN1 (0.53) | MAPTRAB9ASMN1; SMN2TDP1KMT2A | |
| SCHEMBL28279915 | 0.87 | MEN1 (0.49) | SMOTDP1KMT2AMEN1L3MBTL1 | |
| SCHEMBL28422093 | 0.86 | MEN1 (0.48) | SMOMAPTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL27972308 | 0.85 | MEN1 (0.50) | MAPTMAPK1RAB9ASMN1; SMN2TDP1 | |
| SCHEMBL28427586 | 0.84 | JAK2 (0.52) | MAPTMAPK1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL28259959 | 0.84 | CHRNB2 (0.40) | KMT2AMEN1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110483423-A | P2X4 receptor antagonist | NIPPON CHEMIPHAR CO | 2019-11-22 | — | — | CN | disclosed |
| CN-108863959-A | P2X4 RECEPTOR ANTAGONIST | 日本化学药品株式会社 | 2018-11-23 | — | — | CN | disclosed |
| CN-104066724-A | P2X4 receptor antagonists | NIPPON CHEMIPHAR CO | 2014-09-24 | — | — | CN | disclosed |