Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.45 |
| ▸ | LCLAT1 | Q6UWP7 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMO | Q99835 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27972572 | 0.89 | RAB9A (0.53) | NR1H4LCLAT1GAAPOLBSMN1; SMN2 | |
| SCHEMBL27972549 | 0.88 | SMO (0.53) | SMN1; SMN2MAPTMEN1KMT2ASMO | |
| SCHEMBL28427586 | 0.87 | JAK2 (0.52) | NR1H4GAAPOLBSMN1; SMN2MAPT | |
| SCHEMBL27972608 | 0.85 | KCNK3 (0.50) | GAAPOLBSMN1; SMN2MAPTKDM4E | |
| SCHEMBL28425371 | 0.84 | RAB9A (0.47) | GAAPOLBSMN1; SMN2MAPTKDM4E | |
| SCHEMBL27972279 | 0.84 | FADS1 (0.39) | POLBSMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL28426457 | 0.82 | CHRNB2 (0.43) | NR1H4GAAPOLBSMN1; SMN2MEN1 | |
| SCHEMBL28261342 | 0.82 | MEN1 (0.52) | GAAMAPTKDM4EMEN1KMT2A | |
| SCHEMBL27972293 | 0.81 | RAB9A (0.54) | GAAPOLBSMN1; SMN2MAPTKDM4E | |
| SCHEMBL27972308 | 0.80 | MEN1 (0.50) | GAASMN1; SMN2MAPTKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108863959-B | P2X4 receptor antagonists | 日本化学药品株式会社 | 2021-11-30 | — | — | CN | disclosed |
| CN-111333588-A | P2X4 receptor antagonists | 日本化学药品株式会社 | 2020-06-26 | — | — | CN | disclosed |