Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | STAT3 | P40763 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28866664 | 0.90 | PTPN1 (0.52) | KDM4EGAAHTTSMN1; SMN2POLB | |
| SCHEMBL27972271 | 0.88 | RAB9A (0.53) | KDM4ELMNATDP1GAASMN1; SMN2 | |
| SCHEMBL28259952 | 0.87 | PTPN1 (0.52) | KDM4ESMN1; SMN2POLBSTAT3KCNK3 | |
| SCHEMBL27972353 | 0.84 | NAMPT (0.51) | KDM4ELMNATDP1GAASMN1; SMN2 | |
| SCHEMBL27972286 | 0.81 | IDO1 (0.41) | POLBTYK2L3MBTL1NPC1ALDH1A1 | |
| SCHEMBL28813725 | 0.80 | GRM1 (0.46) | KDM4E | |
| SCHEMBL27972621 | 0.80 | NPC1 (0.42) | KDM4ETDP1GAASMN1; SMN2POLB | |
| SCHEMBL28261356 | 0.80 | MAPT (0.49) | KDM4ELMNATDP1HTTSMN1; SMN2 | |
| SCHEMBL27972308 | 0.80 | MEN1 (0.50) | KDM4ELMNATDP1GAAHTT | |
| SCHEMBL27972550 | 0.80 | GRM1 (0.43) | KDM4ESMN1; SMN2POLBNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108863959-B | P2X4 receptor antagonists | 日本化学药品株式会社 | 2021-11-30 | — | — | CN | disclosed |
| CN-111333588-A | P2X4 receptor antagonists | 日本化学药品株式会社 | 2020-06-26 | — | — | CN | disclosed |
| CN-110483423-A | P2X4 receptor antagonist | NIPPON CHEMIPHAR CO | 2019-11-22 | — | — | CN | disclosed |
| CN-108863959-A | P2X4 RECEPTOR ANTAGONIST | 日本化学药品株式会社 | 2018-11-23 | — | — | CN | disclosed |
| CN-104066724-A | P2X4 receptor antagonists | NIPPON CHEMIPHAR CO | 2014-09-24 | — | — | CN | disclosed |