Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | TSHR | P16473 | 6/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | ELANE | P08246 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methacrylic Acid SCHEMBL13726862 | 0.89 | ALDH1A1 (0.50) | ALDH1A1TSHRHSD17B10TDP1THRB | |
| Methacrylic Acid SCHEMBL28105268 | 0.89 | ALDH1A1 (0.50) | ALDH1A1TSHRHSD17B10TDP1THRB | |
| Methacrylic Acid SCHEMBL6017696 | 0.89 | ALDH1A1 (0.50) | ALDH1A1TSHRHSD17B10TDP1THRB | |
| Methacrylic Acid SCHEMBL27989614 | 0.87 | LMNA (0.43) | ALDH1A1TSHRTP53ALOX15HSD17B10 | |
| Methacrylic Acid SCHEMBL28034418 | 0.86 | ALDH1A1 (0.48) | ALDH1A1TSHRHSD17B10TDP1THRB | |
| Maleic Acid SCHEMBL6227317 | 0.83 | TSHR (0.56) | ALDH1A1TSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL63722 | 0.83 | TSHR (0.56) | ALDH1A1TSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL382027 | 0.83 | TSHR (0.56) | ALDH1A1TSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL382028 | 0.83 | TSHR (0.56) | ALDH1A1TSHRTP53EGLN1EGLN3 | |
| Acrylic Acid SCHEMBL27487408 | 0.82 | LMNA (0.48) | ALDH1A1TSHRTP53ALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104395824-A | Alkali developable photosensitive composition | ADEKA CORP | 2015-03-04 | — | — | CN | disclosed |
| CN-104035281-A | Photocuring Composition | ADEKA CORP | 2014-09-10 | — | — | CN | disclosed |