Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 3/20 | 0.38 |
| ▸ | NOS1 | P29475 | 3/20 | 0.38 |
| ▸ | NOS2 | P35228 | 3/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL221161 | 0.84 | NOS1 (0.57) | KDM4EALDH1A1POLBNOS3NOS1 | |
| SCHEMBL4282781 | 0.82 | NOS1 (0.54) | KDM4EALDH1A1NOS3NOS1NOS2 | |
| SCHEMBL4858606 | 0.81 | NOS3 (0.47) | KDM4EALDH1A1POLBLTA4HNOS3 | |
| SCHEMBL4858610 | 0.79 | MCHR1 (0.44) | KDM4EALDH1A1POLBLTA4HNOS3 | |
| SCHEMBL27981548 | 0.79 | PTPN1 (0.48) | KDM4EALDH1A1POLBLTA4HPTPN1 | |
| SCHEMBL27981560 | 0.79 | UTS2R (0.39) | NOS3NOS1NOS2 | |
| SCHEMBL27981872 | 0.76 | LTA4H (0.53) | POLBLTA4HMCHR1 | |
| SCHEMBL27981855 | 0.74 | SMN1; SMN2 (0.49) | KDM4EALDH1A1NOS3NOS1NOS2 | |
| SCHEMBL4858622 | 0.74 | KDM4E (0.43) | KDM4EALDH1A1POLBLTA4HMCHR1 | |
| SCHEMBL7080400 | 0.73 | NOS1 (0.68) | POLBNOS3NOS1NOS2MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101316853-B | Benzothiazole and thiazolopyridine as SIRTUIN modulators | SIRTRIS PHARMACEUTICALS INC | 2014-09-24 | — | — | CN | disclosed |