Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4858610 | 0.79 | MCHR1 (0.44) | KDM4EALDH1A1LTA4HPOLBMCHR1 | |
| SCHEMBL4858606 | 0.76 | NOS3 (0.47) | KDM4EALDH1A1LTA4HPOLBHTR2C | |
| SCHEMBL221161 | 0.75 | NOS1 (0.57) | KDM4EALDH1A1POLBMCHR1 | |
| SCHEMBL27981558 | 0.74 | KDM4E (0.44) | KDM4EALDH1A1LTA4HPOLBMCHR1 | |
| SCHEMBL14970720 | 0.64 | KDM4E (0.60) | KDM4EALDH1A1LTA4H | |
| SCHEMBL7080400 | 0.64 | NOS1 (0.68) | POLBMCHR1 | |
| SCHEMBL12661473 | 0.63 | POLB (0.73) | ALDH1A1LTA4HPOLBHTR2C | |
| SCHEMBL14970454 | 0.63 | KDM4E (0.59) | KDM4EALDH1A1 | |
| SCHEMBL7982480 | 0.62 | MAPK10 (0.69) | KDM4EALDH1A1EGFR | |
| SCHEMBL5572479 | 0.61 | NOS1 (0.56) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910362-A1 | IMIDAZOPYRIDINE DERIVATIVES AS SIRTUIN MODULATING AGENTS | Sirtris Pharmaceuticals, Inc. (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007019345-A1 | IMIDAZOPYRIDINE DERIVATIVES AS SIRTUIN MODULATING AGENTS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2007-02-15 | — | — | WO | disclosed |