Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | ILK | Q13418 | 7/20 | 0.45 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.45 |
| ▸ | AKT2 | P31751 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.36 |
| ▸ | PRKDC | P78527 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5726564 | 0.78 | MAPK1 (0.54) | MAPK1NPSR1ILKRPS6KA3AKT2 | |
| SCHEMBL27997668 | 0.77 | AURKA (0.50) | NPSR1RPS6KA3KMT2AAURKAHSP90AA1 | |
| SCHEMBL5726072 | 0.76 | TGFBR1 (0.48) | RPS6KA3AKT2AURKAPRKACAMAPK14 | |
| SCHEMBL5725765 | 0.74 | PRKCD (0.53) | MAPK1NPSR1ILKRPS6KA3KMT2A | |
| SCHEMBL6070210 | 0.73 | TGFBR1 (0.56) | RPS6KA3AKT2AURKAPRKACAMAPK14 | |
| SCHEMBL5258699 | 0.70 | HSP90AA1 (0.55) | MAPK1NPSR1ILKRPS6KA3AKT2 | |
| SCHEMBL5820038 | 0.70 | MAPK1 (1.00) | MAPK1NPSR1ILKRPS6KA3AKT2 | |
| SCHEMBL5777962 | 0.69 | ALDH1A1 (0.52) | MAPK1NPSR1KMT2AKDM4EALDH1A1 | |
| SCHEMBL5257436 | 0.67 | CHEK1 (0.46) | MAPK1NPSR1ILKRPS6KA3AKT2 | |
| SCHEMBL6132051 | 0.67 | MAPK1 (0.83) | MAPK1NPSR1ILKRPS6KA3AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1455579-B1 | PYRAZOLES-PYRIMIDINE FUNGICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2006-09-06 | — | — | EP | disclosed |
| US-20050080101-A1 | Pyrazoles-pyrimidine fungicides | SYNGENTA CROP PROTECTION, INC. | 2005-04-14 | — | — | US | disclosed |
| EP-1455579-A1 | PYRAZOLES-PYRIMIDINE FUNGICIDES | Syngenta Participations AG (CH) | 2004-09-15 | — | — | EP | disclosed |
| WO-2003049542-A1 | PYRAZOLES-PYRIMIDINE FUNGICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2003-06-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050080101-A1 | Pyrazoles-pyrimidine fungicides | DHFR, CYP3A7, CBR3 | MAPK1 2728/4885NPSR1 2243/4885ILK 4793/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.