Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27854322 | 0.79 | CYP2C19 (0.48) | CYP2C19KDM4EKMT2AMAPK1GABRA1 | |
| SCHEMBL30901780 | 0.75 | AR (0.58) | HTR6CYP2C19IMPDH2KDM4EKMT2A | |
| SCHEMBL6811813 | 0.74 | KDM4E (0.45) | HTR6KDM4EKMT2ALMNAHTT | |
| SCHEMBL1082317 | 0.72 | ALDH1A1 (0.42) | HTR6CYP2C19KDM4EKMT2AMAPT | |
| SCHEMBL27592344 | 0.72 | NOTUM (0.42) | KDM4EKMT2AMAPTADRA1DRAB9A | |
| SCHEMBL23064484 | 0.71 | HTR1A (0.38) | KDM4EKMT2AMAPT | |
| SCHEMBL23064587 | 0.71 | FFAR1 (0.46) | KMT2A | |
| SCHEMBL2782013 | 0.69 | LMNA (0.51) | HTR6KDM4EKMT2ALMNAHTT | |
| SCHEMBL6407264 | 0.68 | LMNA (0.51) | HTR6KDM4EKMT2ALMNAHTT | |
| SCHEMBL28256158 | 0.68 | DRD2 (0.45) | KDM4EKMT2ALMNAHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104357505-A | Indol-pyrrolidine -2-ketone alkaloid and preparation method and application thereof | UNIV YUNNAN NATIONALITIES | 2015-02-18 | — | — | CN | claimed |
| CN-104357505-A | Indol-pyrrolidine -2-ketone alkaloid and preparation method and application thereof | UNIV YUNNAN NATIONALITIES | 2015-02-18 | — | — | CN | disclosed |
| CN-104357505-A | Indol-pyrrolidine -2-ketone alkaloid and preparation method and application thereof | UNIV YUNNAN NATIONALITIES | 2015-02-18 | — | — | CN | disclosed |
| CN-104357505-A | Indol-pyrrolidine -2-ketone alkaloid and preparation method and application thereof | UNIV YUNNAN NATIONALITIES | 2015-02-18 | — | — | CN | disclosed |