Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | HTR6 | P50406 | 2/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1413377 | 0.98 | HTT (0.54) | LMNAKDM4EHTTMAPK1JAK2 | |
| Hydrochloric Acid SCHEMBL11852231 | 0.96 | JAK2 (0.55) | LMNAKDM4EHTTMAPK1JAK2 | |
| SCHEMBL6407264 | 0.92 | LMNA (0.51) | LMNAKDM4EHTTMAPK1BCHE | |
| SCHEMBL16801682 | 0.87 | HTR6 (0.56) | LMNAKDM4ECYP2D6HTR2AHTR6 | |
| SCHEMBL1442314 | 0.85 | HTR6 (0.63) | LMNAKDM4ECYP2D6HTR2AHTR6 | |
| SCHEMBL1413397 | 0.84 | HTR6 (0.56) | LMNAKDM4EHTTPOLBHTR2A | |
| SCHEMBL7548171 | 0.84 | BCHE (0.44) | LMNAKDM4EHTTMAPK1JAK2 | |
| SCHEMBL1413396 | 0.84 | ALDH1A1 (0.55) | LMNAKDM4ECYP2D6KMT2AMAPT | |
| SCHEMBL21047718 | 0.82 | BCHE (0.42) | LMNAKDM4EHTTJAK2RAB9A | |
| SCHEMBL21047732 | 0.81 | ALDH1A1 (0.41) | LMNAKDM4EHTTMAPK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7368470-B2 | Substituted 3-pyrrolidine-indole derivatives | GRUENENTHAL GMBH (DE) | 2008-05-06 | — | — | US | claimed |
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | claimed |
| US-20050096376-A1 | Substituted 3-pyrrolidine-indole derivatives | GRUENENTHAL GMBH (DE) | 2005-05-05 | — | — | US | claimed |
| CN-1047386-C | Novel spiro [indole-pyrrolidine]derivatives as melatoninergic agonists, method for preparing same and use thereof as drug | CEMAF (FR) | 1999-12-15 | — | — | CN | claimed |
| US-5763471-A | TREATS PSYCHIATARIC AND BRAIN DISORDERS | CEMAF (FR) | 1998-06-09 | — | — | US | claimed |
| CN-1148855-A | Novel spiro [indole-pyrrolidine]derivatives as melatoninergic agonists, method for preparing same and use thereof as drug | CEMAF (FR) | 1997-04-30 | — | — | CN | claimed |
| CN-119930875-A | Composite catalyst and preparation method of cycloolefin copolymer using same | 金发科技股份有限公司 | 2025-05-06 | — | — | CN | disclosed |
| WO-2024026574-A1 | 3-PYRROLIDINE-INDOLE DIMERS AS SEROTONERGIC AGENTS USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | MINDSET PHARMA INC. (CA) | 2024-02-08 | — | — | WO | disclosed |
| US-20230105399-A1 | 3-PYRROLIDINE-INDOLE DERIVATIVES AS SEROTONERGIC PSYCHEDELIC AGENTS FOR THE TREATMENT OF CNS DISORDERS | MINDSET PHARMA INC. (CA) | 2023-04-06 | — | — | US | disclosed |
| EP-4100403-A1 | 3-PYRROLIDINE-INDOLE DERIVATIVES AS SEROTONERGIC PSYCHEDELIC AGENTS FOR THE TREATMENT OF CNS DISORDERS | Mindset Pharma Inc. (CA) | 2022-12-14 | — | — | EP | disclosed |
| CN-115380028-A | 3-pyrrolidine-indole derivatives as serotonergic hallucinogens for the treatment of CNS disorders | 明德赛特制药公司 | 2022-11-22 | — | — | CN | disclosed |
| CN-115380028-A | 3-pyrrolidine-indole derivatives as serotonergic hallucinogens for the treatment of CNS disorders | 明德赛特制药公司 | 2022-11-22 | — | — | CN | disclosed |
| US-20220133740-A1 | VALPROIC ACID COMPOUNDS AND WNT AGONISTS FOR TREATING EAR DISORDERS | Frequency Therapeutics, Inc. (US) | 2022-05-05 | — | — | US | disclosed |
| US-20050096376-A1 | Substituted 3-pyrrolidine-indole derivatives | GRUENENTHAL GMBH (DE) | 2005-05-05 | — | — | US | disclosed |
| US-20050075348-A1 | Functionalized heterocycles as modulators of chemokine receptor function and methods of use therefor | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-04-07 | — | — | US | disclosed |
| WO-2005019208-A1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | Grünenthal GmbH (DE) | 2005-03-03 | — | — | WO | disclosed |
| WO-2005019208-A1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | Grünenthal GmbH (DE) | 2005-03-03 | — | — | WO | disclosed |
| US-20030064991-A1 | Functionalized heterocycles as modulators of chemokine receptor function and methods of use therefor | MILLENNIUM PHARMACEUTICALS, INC. | 2003-04-03 | — | — | US | disclosed |
| CN-1047386-C | Novel spiro [indole-pyrrolidine]derivatives as melatoninergic agonists, method for preparing same and use thereof as drug | CEMAF (FR) | 1999-12-15 | — | — | CN | disclosed |
| CN-1148855-A | Novel spiro [indole-pyrrolidine]derivatives as melatoninergic agonists, method for preparing same and use thereof as drug | CEMAF (FR) | 1997-04-30 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030064991-A1 | Functionalized heterocycles as modulators of chemokine receptor function and methods of use therefor | ACKR3, CCR5, CXCR4 | LMNA 4828/4885KDM4E 3859/4885HTT 4710/4885 |
| US-20050075348-A1 | Functionalized heterocycles as modulators of chemokine receptor function and methods of use therefor | ACKR3, CCR5, CXCR4 | LMNA 4803/4885KDM4E 3850/4885HTT 4668/4885 |
| US-20230105399-A1 | 3-PYRROLIDINE-INDOLE DERIVATIVES AS SEROTONERGIC PSYCHEDELIC AGENTS FOR THE TREATMENT OF CNS DISORDERS | HTR3A, TPH1, HTR5A | LMNA 2030/4885KDM4E 3617/4885HTT 431/4885 |
| US-20220133740-A1 | VALPROIC ACID COMPOUNDS AND WNT AGONISTS FOR TREATING EAR DISORDERS | WNT3A, WNT1, WNT3 | LMNA 1856/4885KDM4E 853/4885HTT 3254/4885 |
| US-20050096376-A1 | Substituted 3-pyrrolidine-indole derivatives | OPRD1, OPRK1, TPH1 | LMNA 3265/4885KDM4E 1917/4885HTT 358/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.