Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 2/20 | 0.49 |
| ▸ | DRD2 | P14416 | 5/20 | 0.49 |
| ▸ | DRD4 | P21917 | 4/20 | 0.49 |
| ▸ | DRD3 | P35462 | 4/20 | 0.49 |
| ▸ | HTR6 | P50406 | 2/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2782013 | 0.92 | LMNA (0.51) | LMNAHTTGAABCHECYP2D6 | |
| SCHEMBL1413397 | 0.91 | HTR6 (0.56) | LMNAHTTGAAHTR1ADRD2 | |
| SCHEMBL1413377 | 0.90 | HTT (0.54) | LMNAHTTGAABCHECYP2D6 | |
| SCHEMBL1442314 | 0.89 | HTR6 (0.63) | LMNACYP2D6HTR1AHTR6ADRB1 | |
| Hydrochloric Acid SCHEMBL11852231 | 0.89 | JAK2 (0.55) | LMNAHTTGAABCHECYP2D6 | |
| SCHEMBL1413396 | 0.87 | ALDH1A1 (0.55) | LMNACYP2D6DRD2KDM4EALDH1A1 | |
| SCHEMBL7548171 | 0.87 | BCHE (0.44) | LMNAHTTGAABCHECYP2D6 | |
| SCHEMBL21047718 | 0.86 | BCHE (0.42) | LMNAHTTGAABCHECYP2D6 | |
| SCHEMBL18324896 | 0.85 | LMNA (0.45) | LMNAHTTGAABCHECYP2D6 | |
| SCHEMBL26912673 | 0.85 | MAPT (0.59) | LMNAHTTCYP2D6DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6841685-B2 | Methods for making bis-heterocyclic alkaloids | STATE OF OREGON ACTING BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF OREGON STATE UNIVERSITY (US) | 2005-01-11 | — | — | US | disclosed |
| US-20030232988-A1 | Methods for making bis-heterocyclic alkaloids | STATE OF OREGON ACTING BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF OREGON STATE UNIVERSITY,THE | 2003-12-18 | — | — | US | disclosed |
| WO-2001094310-A1 | METHODS FOR MAKING BIS-HETEROCYCLIC ALKALOIDS | THE STATE OF OREGON ACTING BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF OREGON STATE UNIVERSITY (US) | 2001-12-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030232988-A1 | Methods for making bis-heterocyclic alkaloids | CIAPIN1, AAAS, MDN1 | LMNA 1516/4885HTT 175/4885GAA 3984/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.