Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | HSPB1 | P04792 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MYOC | Q99972 | 1/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28819079 | 0.85 | ALDH1A1 (0.39) | ALDH1A1HTTHSPB1KDM4EKMT2A | |
| SCHEMBL28014368 | 0.83 | TDP1 (0.38) | ALDH1A1HTTHSPB1KDM4EKMT2A | |
| SCHEMBL3174443 | 0.80 | HSPB1 (0.51) | ALDH1A1HTTHSPB1KDM4EKMT2A | |
| Tert-Butyl Formate SCHEMBL28819128 | 0.80 | HSPB1 (0.47) | ALDH1A1HTTHSPB1KDM4EKMT2A | |
| SCHEMBL28070177 | 0.73 | LMNA (0.44) | ALDH1A1HTTHSPB1KDM4EKMT2A | |
| SCHEMBL3173025 | 0.73 | ALDH1A1 (0.49) | ALDH1A1HTTHSPB1KDM4EKMT2A | |
| SCHEMBL24168164 | 0.73 | HSPB1 (0.51) | ALDH1A1HTTHSPB1KDM4EKMT2A | |
| SCHEMBL1890124 | 0.73 | ALDH1A1 (0.59) | ALDH1A1HTTHSPB1KDM4EKMT2A | |
| SCHEMBL3552198 | 0.73 | ALDH1A1 (0.59) | ALDH1A1HTTHSPB1KDM4EKMT2A | |
| SCHEMBL28227048 | 0.73 | HSPB1 (0.51) | ALDH1A1HTTHSPB1KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108997208-A | A kind of preparation method of Sorafenib | 山东罗欣药业集团恒欣药业有限公司 | 2018-12-14 | — | — | CN | disclosed |
| CN-105085388-B | A kind of synthetic method of Sorafenib intermediate | 合肥华方医药科技有限公司 | 2018-07-13 | — | — | CN | disclosed |
| CN-105085388-A | Synthesis method for sorafenib intermediate | HEFEI HUAFANG PHARMACEUTICAL SCIENCES & TECHNOLOGY CO LTD | 2015-11-25 | — | — | CN | disclosed |
| CN-104557688-A | Synthetic method for Sorafenib intermediate and synthetic method for compound A used for synthesizing Sorafenib intermediate | ASYMCHEM LAB TIANJIN CO LTD | 2015-04-29 | — | — | CN | disclosed |