Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MYOC | Q99972 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28014374 | 0.78 | MEN1 (0.51) | LMNAALDH1A1HSPB1KDM4EMEN1 | |
| SCHEMBL2470643 | 0.77 | SCN4A (0.47) | LMNAALDH1A1HSPB1KDM4EMEN1 | |
| SCHEMBL3552198 | 0.74 | ALDH1A1 (0.59) | LMNAALDH1A1HSPB1KDM4EMEN1 | |
| SCHEMBL28227048 | 0.74 | HSPB1 (0.51) | LMNAALDH1A1HSPB1KDM4EMEN1 | |
| SCHEMBL1890124 | 0.74 | ALDH1A1 (0.59) | LMNAALDH1A1HSPB1KDM4EMEN1 | |
| SCHEMBL24168164 | 0.74 | HSPB1 (0.51) | LMNAALDH1A1HSPB1KDM4EMEN1 | |
| SCHEMBL28014355 | 0.73 | ALDH1A1 (0.43) | LMNAALDH1A1HSPB1KDM4EMEN1 | |
| SCHEMBL7284511 | 0.73 | NOS2 (0.54) | ALDH1A1KDM4EHTTMAPTCRHBP | |
| SCHEMBL3173025 | 0.71 | ALDH1A1 (0.49) | LMNAALDH1A1HSPB1KDM4EMEN1 | |
| SCHEMBL3997433 | 0.70 | HSPB1 (0.63) | LMNAALDH1A1HSPB1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105646448-B | Pyridine compounds and their and application thereof | 沈阳药科大学 | 2019-03-01 | — | — | CN | disclosed |
| CN-108997208-A | A kind of preparation method of Sorafenib | 山东罗欣药业集团恒欣药业有限公司 | 2018-12-14 | — | — | CN | disclosed |
| CN-105646448-A | Pyridine compounds and application thereof | 沈阳药科大学 | 2016-06-08 | — | — | CN | disclosed |