Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 4/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | SLC18A3 | Q16572 | 3/20 | 0.34 |
| ▸ | QDPR | P09417 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.33 |
| ▸ | CCR1 | P32246 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28822639 | 0.89 | ALDH1A1 (0.36) | NAMPTRIPK1CYP2C9ALDH1A1MAPT | |
| SCHEMBL27318172 | 0.83 | SLC18A3 (0.44) | NAMPTRIPK1CYP3A4CYP2C9SLC18A3 | |
| SCHEMBL27594938 | 0.83 | DRD2 (0.48) | NAMPTSLC18A3CCR1 | |
| SCHEMBL27629058 | 0.83 | NAMPT (0.41) | NAMPTRIPK1CYP3A4CYP2C9ALDH1A1 | |
| SCHEMBL27562125 | 0.83 | PARP10 (0.44) | NAMPTALDH1A1MAPTCCR1 | |
| SCHEMBL27488566 | 0.82 | RIPK1 (0.51) | NAMPTRIPK1ALDH1A1SLC18A3 | |
| SCHEMBL28014736 | 0.81 | FAAH (0.42) | NAMPTALDH1A1MAPTGPR119 | |
| SCHEMBL27622593 | 0.81 | NAMPT (0.40) | NAMPTRIPK1CYP3A4CYP2C9ALDH1A1 | |
| SCHEMBL28059915 | 0.81 | CYP2C9 (0.51) | NAMPTCYP2C9ALDH1A1MAPTGPR119 | |
| SCHEMBL27745535 | 0.80 | LMNA (0.48) | NAMPTRIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104662006-A | Quinazolinone derivatives as PARP inhibitors | MERCK PATENT GMBH | 2015-05-27 | — | — | CN | disclosed |