Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 2/20 | 0.40 |
| ▸ | FLT3 | P36888 | 2/20 | 0.40 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.40 |
| ▸ | MERTK | Q12866 | 2/20 | 0.40 |
| ▸ | GUCY1A1 | Q02108 | 3/20 | 0.39 |
| ▸ | GUCY1B1 | Q02153 | 3/20 | 0.39 |
| ▸ | SPR | P35270 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2801440 | 0.90 | PDE2A (0.47) | PDE2AJAK2JAK1TYK2JAK3 | |
| SCHEMBL2801257 | 0.89 | PDE2A (0.44) | PDE2AAXLFLT3TYRO3MERTK | |
| SCHEMBL2800063 | 0.82 | SPR (0.44) | GUCY1A1GUCY1B1SPRALDH1A1L3MBTL1 | |
| SCHEMBL2800936 | 0.80 | STAT6 (0.42) | SPRALDH1A1L3MBTL1 | |
| SCHEMBL2801102 | 0.80 | SIRT5 (0.50) | SPRALDH1A1L3MBTL1MAPTHPGD | |
| SCHEMBL2801085 | 0.80 | PDE4B (0.44) | SPRALDH1A1L3MBTL1MAPTNPSR1 | |
| SCHEMBL2799831 | 0.80 | ALDH1A1 (0.47) | SPRALDH1A1L3MBTL1MAPTNPSR1 | |
| SCHEMBL2801606 | 0.80 | PDE4B (0.48) | SPRALDH1A1L3MBTL1MAPTTSHR | |
| SCHEMBL2798969 | 0.80 | SCD5 (0.44) | SPRALDH1A1L3MBTL1TSHRSCD5 | |
| SCHEMBL2801745 | 0.79 | SPR (0.41) | SPRALDH1A1L3MBTL1TSHRSCD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2206714-B1 | AGENT FOR PREVENTION AND/OR TREATMENT OF SKIN DISEASES | KYOWA HAKKO KIRIN CO LTD (JP) | 2015-01-21 | — | — | EP | disclosed |
| US-8729264-B2 | Agent for prevention and/or treatment of skin diseases | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2014-05-20 | — | — | US | disclosed |
| US-20100256134-A1 | AGENT FOR PREVENTION AND/OR TREATMENT OF SKIN DISEASES | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2010-10-07 | — | — | US | disclosed |
| EP-2206714-A1 | AGENT FOR PREVENTION AND/OR TREATMENT OF SKIN DISEASES | Kyowa Hakko Kirin Co., Ltd. (JP) | 2010-07-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256134-A1 | AGENT FOR PREVENTION AND/OR TREATMENT OF SKIN DISEASES | TYR, CUTA, SERPINB1 | PDE2A 813/4885JAK2 857/4885JAK1 210/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.