Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.45 |
| ▸ | AGER | Q15109 | 3/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | UBE2M | P61081 | 2/20 | 0.41 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9456418 | 0.86 | AGER (0.58) | CCR5CYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1964546 | 0.85 | HSD11B1 (0.53) | CCR5OPRM1AGERMTNR1ACHRM2 | |
| SCHEMBL566741 | 0.85 | AGER (0.49) | OPRM1AGERMTNR1ACHRM2CHRM3 | |
| SCHEMBL803784 | 0.85 | CCR5 (0.45) | CCR5OPRM1AGERMTNR1ACHRM2 | |
| SCHEMBL27596342 | 0.84 | CCR5 (0.48) | CCR5CYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6482118 | 0.78 | CCR5 (0.43) | CCR5CYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6482121 | 0.78 | CCR5 (0.43) | CCR5CYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL29372829 | 0.78 | UBE2M (0.42) | OPRM1UBE2MDCUN1D1 | |
| SCHEMBL8768757 | 0.77 | DRD2 (0.42) | CCR5CYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9998343 | 0.77 | CCR5 (0.55) | CCR5L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104906100-A | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases | ABBOTT LAB | 2015-09-16 | — | — | CN | disclosed |
| CN-104876927-A | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | ABBOTT LAB | 2015-09-02 | — | — | CN | disclosed |
| CN-102448959-B | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases | ABBVIE BAHAMAS LTD | 2015-06-17 | — | — | CN | disclosed |