Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP7 | P09237 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.37 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.37 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28022345 | 0.85 | PTGS2 (0.44) | — | |
| SCHEMBL28022361 | 0.80 | TSHR (0.42) | TSHRSMN1; SMN2HTT | |
| SCHEMBL28159883 | 0.79 | KMT2A (0.54) | HSD11B1TSHRSMN1; SMN2CNR1LMNA | |
| SCHEMBL28847087 | 0.79 | TSHR (0.54) | HSD11B1TSHRSMN1; SMN2CNR1LMNA | |
| SCHEMBL28022383 | 0.78 | SFRP1 (0.44) | TSHRLMNAKMT2AALDH1A1HTT | |
| SCHEMBL28022378 | 0.77 | PDK1 (0.39) | MMP7 | |
| SCHEMBL28022416 | 0.76 | POLB (0.46) | MMP7PTPN1PTPN2PTPN5LMNA | |
| SCHEMBL28160266 | 0.75 | RORC (0.42) | HSD11B1TSHRSMN1; SMN2CNR1MEN1 | |
| SCHEMBL28820911 | 0.74 | RORC (0.49) | TSHRSMN1; SMN2PTPN1 | |
| SCHEMBL10763658 | 0.73 | MEP1B (0.55) | MMP7TSHRSMN1; SMN2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105102449-B | Antiviral compound | 豪夫迈·罗氏有限公司 | 2017-06-13 | — | — | CN | disclosed |
| CN-105102449-A | Antiviral compounds | HOFFMANN LA ROCHE | 2015-11-25 | — | — | CN | disclosed |