SCHEMBL28025019

SCHEMBL28025019

[N-]=[N+]=NC(=O)c1cccc(-c2cccc(Cl)c2)c1-c1cccc(Cl)c1

nearest known ligand 0.42

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
RORB Q92753 4/20 0.42
SLC9A1 P19634 4/20 0.39
RORC P51449 2/20 0.39
CHRM1 P11229 3/20 0.37
CHRM2 P08172 2/20 0.37
CHRM4 P08173 2/20 0.37
CHRM3 P20309 2/20 0.37
CA12 O43570 1/20 0.35
CA9 Q16790 1/20 0.35
DCLRE1B Q9H816 1/20 0.35
HSP90AA1 P07900 1/20 0.34
HSP90AB1 P08238 1/20 0.34
GPR35 Q9HC97 1/20 0.34
RXRA P19793 1/20 0.34
RXRB P28702 1/20 0.34
PARP1 P09874 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28025572 0.89 RORB (0.47) RORBSLC9A1RORCCHRM1CHRM2
SCHEMBL28821428 0.86 SLC9A1 (0.42) RORBSLC9A1RORCCHRM1CHRM2
SCHEMBL28151007 0.71 PARP1 (0.52) PARP1
SCHEMBL15245370 0.70 ALDH1A1 (0.39)
SCHEMBL28835173 0.70 CA1 (0.55)
SCHEMBL10631523 0.70 RORB (0.57) RORBRORCCHRM1CHRM2CHRM4
SCHEMBL28117118 0.69 PTPN1 (0.36) RORBRORCCA12CA9
SCHEMBL269867 0.68 HNF4A (0.53) RORBCHRM1CHRM2CHRM4CHRM3
SCHEMBL8817729 0.68 PARP1 (0.47) PARP1
SCHEMBL3632126 0.67 BCAT2 (0.65) RORBSLC9A1RORCCHRM1CHRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104918612-A FUNCTIONALIZED BENZAMIDE DERIVATIVES AS ANTIVIRAL AGENTS AGAINST HBV INFECTION INST HEPATITIS & VIRUS RES 2015-09-16 CN claimed
CN-104918612-A FUNCTIONALIZED BENZAMIDE DERIVATIVES AS ANTIVIRAL AGENTS AGAINST HBV INFECTION INST HEPATITIS & VIRUS RES 2015-09-16 CN disclosed