Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 11/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 11/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.38 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30516424 | 0.82 | MTOR (0.52) | MTORCHEK1ATRPDCD1ATRIP | |
| SCHEMBL27866890 | 0.82 | CHRNB2 (0.41) | CHRNB2CHRNA4CHRNB4CHRNA3MAPT | |
| SCHEMBL137068 | 0.80 | LMNA (0.47) | MAPTPIK3C3 | |
| SCHEMBL28024733 | 0.75 | POLB (0.35) | MAPTHTT | |
| SCHEMBL29442130 | 0.72 | CHRNB2 (0.59) | CHRNB2CHRNA4MAPTHTT | |
| SCHEMBL256566 | 0.72 | CHRNB2 (0.59) | CHRNB2CHRNA4MAPTHTT | |
| SCHEMBL28024741 | 0.71 | HTR3A (0.33) | PIK3C3 | |
| SCHEMBL27866878 | 0.71 | GRIN2D (0.40) | MTORATRATRIPPIK3C3 | |
| SCHEMBL28024746 | 0.71 | PIK3CD (0.36) | HTTMTORATRPIK3C3 | |
| SCHEMBL4350327 | 0.70 | LMNA (0.62) | CHRNB2CHRNA4MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105143209-A | Biaryl amide compounds as kinase inhibitors | NOVARTIS AG | 2015-12-09 | — | — | CN | disclosed |