Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | TTK | P33981 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11624564 | 0.83 | ALOX15 (0.41) | ALOX15SMN1; SMN2TP53ALDH1A1KDM4E | |
| SCHEMBL14036889 | 0.83 | KDM4E (0.44) | ALOX15SMN1; SMN2POLBMAPK1ALDH1A1 | |
| SCHEMBL27518476 | 0.80 | ALOX15 (0.35) | ALOX15SMN1; SMN2TP53POLBALDH1A1 | |
| SCHEMBL20449061 | 0.79 | TAAR1 (0.41) | ALOX15SMN1; SMN2ALDH1A1KDM4EHPGD | |
| SCHEMBL11123121 | 0.79 | ALOX15 (0.43) | ALOX15SMN1; SMN2ALDH1A1KDM4EHPGD | |
| SCHEMBL28024865 | 0.79 | ALOX15 (0.37) | ALOX15SMN1; SMN2ALDH1A1KDM4EHPGD | |
| SCHEMBL5584092 | 0.79 | GPR84 (0.49) | ALOX15MAPK1ALDH1A1MAPT | |
| SCHEMBL14094653 | 0.76 | RIPK1 (0.42) | ALOX15SMN1; SMN2ALDH1A1KDM4EHPGD | |
| SCHEMBL28861332 | 0.75 | ALOX15 (0.43) | ALOX15SMN1; SMN2TP53ALDH1A1KDM4E | |
| SCHEMBL28583866 | 0.75 | ALOX15 (0.43) | ALOX15SMN1; SMN2ALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102292321-B | Pyrazolyl-substituted carbonic acid derivatives as modulators of the prostacyclin (PGI2) receptor for the treatment of receptor-related disorders | ARENA PHARMACEUTICALS, INC. (US) | 2015-08-12 | — | — | CN | disclosed |