Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Guanine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.59 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.59 |
| ▸ | XDH | P47989 | 1/20 | 0.59 |
| ▸ | HBB | P68871 | 1/20 | 0.59 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | PNP | P00491 | 2/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.50 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanine SCHEMBL342789 | 0.96 | ADORA3 (0.62) | ADORA3ALDH1A1USP2TP53HPGD | |
| Guanine SCHEMBL30070479 | 0.79 | ALDH1A1 (0.42) | ADORA3ALDH1A1USP2TP53HPGD | |
| SCHEMBL1009012 | 0.76 | ACHE (0.50) | ADORA3ALDH1A1USP2TP53HPGD | |
| SCHEMBL8230116 | 0.74 | ACHE (0.48) | ADORA3ALDH1A1USP2TP53HPGD | |
| SCHEMBL1898184 | 0.74 | GDA (0.48) | ADORA3ALDH1A1USP2TP53HPGD | |
| Water SCHEMBL9462016 | 0.74 | ACHE (0.48) | ADORA3ALDH1A1USP2TP53HPGD | |
| Thioguanine SCHEMBL31327802 | 0.74 | ALDH1A1 (1.00) | ADORA3ALDH1A1USP2TP53HPGD | |
| SCHEMBL612212 | 0.74 | ACHE (0.48) | ADORA3ALDH1A1USP2TP53HPGD | |
| Hydrochloric Acid SCHEMBL9666845 | 0.74 | ACHE (0.48) | ADORA3ALDH1A1USP2TP53HPGD | |
| Thioguanine SCHEMBL28134237 | 0.74 | ALDH1A1 (1.00) | ADORA3ALDH1A1USP2TP53HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104798869-A | Preservative for bullfrog meat product | YANTAI SHUNLONG CHEMICAL TECHNOLOGY CO LTD | 2015-07-29 | — | — | CN | disclosed |