Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.58 |
| ▸ | MAOB | P27338 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 4/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.51 |
| ▸ | ASF1A | Q9Y294 | 1/20 | 0.50 |
| ▸ | NHERF1 | O14745 | 2/20 | 0.49 |
| ▸ | GUSB | P08236 | 1/20 | 0.49 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28028260 | 1.00 | MAOA (0.58) | MAOAMAOBTP53POLBEGFR | |
| SCHEMBL28028261 | 0.87 | MMP13 (0.59) | POLBGUSBFAAHNPC1RAB9A | |
| SCHEMBL28028262 | 0.87 | MMP13 (0.59) | POLBGUSBFAAHNPC1RAB9A | |
| SCHEMBL28028254 | 0.81 | MAOA (0.66) | MAOAMAOBTP53POLBEGFR | |
| SCHEMBL10466165 | 0.79 | MAOA (0.71) | MAOAMAOBTP53POLBEGFR | |
| SCHEMBL24601450 | 0.78 | MMP13 (0.72) | MAOAMAOBTP53POLBEGFR | |
| SCHEMBL28028736 | 0.77 | KMT2A (0.70) | POLBASF1ANPC1RAB9AMAPT | |
| SCHEMBL28028734 | 0.77 | KMT2A (0.70) | POLBASF1ANPC1RAB9AMAPT | |
| SCHEMBL28028277 | 0.76 | MAOA (0.63) | MAOAMAOBTP53POLBEGFR | |
| SCHEMBL15974230 | 0.74 | KDM4E (0.60) | POLBASF1ANPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104860866-B | 5- (substitution carbon acylamino) -1H- indoles -2- carbohydrazide derivatives and its preparation method and application | 厦门大学 | 2018-07-17 | — | — | CN | disclosed |
| CN-104860866-A | 5-(substituted carbonylamino)-1H-indole-2-carbohydrazide derivatives as well as preparation method and application thereof | UNIV XIAMEN | 2015-08-26 | — | — | CN | disclosed |